NOW SAMe  

Helps reduce pain associated with Osteoarthritis. SAMe supplementation may be beneficial in osteoarthritisdue to its analgesic and anti-inflammatory effects. SAMe is widely used in Europe for this purpose. NOW SAMe is enteric-coated which makes it very well tolerated and  protects it from degradation. This formulation is also suitable for vegetarians and vegans. It is our most potent SAMe formulation.

SAMe (S-adenosyl-L-methionine) is a naturally occurring substance that is present in the cells of all living organisms. It is a direct metabolite of the essential amino acid, L-methionine. S-adenosylmethionine (SAMe) is distributed throughout virtually all body tissues and fluids. Concentrations are highest in childhood and decrease with age. SAMe plays an essential role in more than 100 biochemical reactions. It contributes to the synthesis, activation and/or metabolism of  hormones, neurotransmitters, nucleic acids, proteins and phospholipids. SAMe is produced in the body by adenosine triphosphate (ATP) activation of methionine. Deficiencies of B12 and folate can result in decreased SAMe concentrations in the central nervous system. Preliminary evidence suggests SAMe might stimulate articular cartilage growth and repair, specifically chondrocyte proteoglycan synthesis. SAMe might also protect against cytokine-induced synovial cell damage.

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